Mysoline is an anticonvulsant drug used to treat those struggling with serious seizure disorders. Although it was created for this reason, it can also help individuals with tremors, a nerve disorder that causes rhythmic shaking. The medication is used to reduce abnormal electrical activity in the brain of people with these conditions and help make them more manageable. 

As suggested by WebMD, individuals taking this drug must keep constant levels of it in their system. “This drug must be taken at evenly spaced intervals. If you abruptly halt use, it might lead to withdrawal symptoms, including hallucinations, twitching, sleep problems, and anxiety. Mysoline withdrawal is oftentimes severe, and in some cases, can cause severe seizures or death. Despite its therapeutic benefits, you should always be careful when using this drug. 

Mysoline falls under a category of drugs that are, for the most part, overlooked by medical professionals due to safer alternatives that scientists have created. Mysoline belongs to a class of drugs known as barbiturates, which were at one point in time what benzodiazepines are today. 

The U.S. Centers for Disease Control and Prevention (CDC) estimates that around 1.2 million percent of the population suffered from epilepsy in 2015, roughly translating to three million adults and 470,000 children. While benzodiazepines are largely used today to treat conditions like epilepsy, it’s not always strong enough to achieve the desired effects, leading to a more potent barbiturate to be used. 

Mysoline is sought out as a last resort treatment because of its effectiveness in managing tremors and epilepsy. Barbiturates are incredibly potent, which is why their use has largely been halted. Not only are they potent, but they’re extremely addictive. Taking slightly more than you’re prescribed can lead to an overdose. For all these reasons, the case must be severe for a doctor to consider using this drug.

Those who use the drug, even as prescribed, can develop a chemical dependency or an addiction to the medicine in a short period. Unfortunately, this can lead to withdrawal upon abrupt cessation or cutting back on the drug. Not only will this cause severe discomfort, but it can also be fatal without seeking professional help. For this reason, if you wish to stop using Mysoline, it’s crucial to seek the proper channels for support. Professional addiction treatment for detox is, quite literally, the difference between life and death. You should never take chances with your life when help is so readily available.

What Are the Mysoline Withdrawal Symptoms?

Those who cease use of Mysoline or significantly lower the dose prescribed by their doctor put themselves at risk of withdrawal symptoms. While the severity of symptoms and how long they last will vary from one person to another, some of the factors that influence this include the person’s age, sex, and overall physical health. For example, one person who uses the drug as prescribed could experience more severe symptoms than a person who abuses the drug based on these factors. Since withdrawal can be unpredictable, it’s hard to give an absolute answer. The list below is a generalized set of symptoms. 

The most likely Mysoline withdrawal symptoms a person will encounter include the following:

  • Stomach cramps
  • Irritability
  • Nausea and vomiting
  • Insomnia
  • Fever
  • Seizures
  • Mood swings and depression
  • Increased chance of severe seizures
  • Heart failure
  • Anxiety
  • Hallucinations
  • Death

It can’t be stressed enough about the severity of Mysoline withdrawal symptoms. The phenomenon is dangerous, and in some cases, if the person doesn’t seek help, it can be fatal. Medical News Today found that a staggering 75 percent of those who withdraw from barbiturates will endure seizures. Another 66 percent could develop delirium that persists for several days.

Stages of Mysoline Withdrawal Timeline

In most cases, the symptoms of Mysoline withdrawal will subside a few weeks after they start. The initial symptoms will take place within the first few days after a person lowers their dose or stops using the drug altogether. However, there’s no definitive timeline or order for how someone will deal with these symptoms due to the factors mentioned above. Other factors include how long someone was using the drug, the size of their last dose, and if they’re using other depressants in conjunction with Mysoline.

It’s vital to mention that the more uncomfortable symptoms you face will also occur in conjunction with minor symptoms. Below we’ll list a generalized Mysoline withdrawal timeline to help you understand what to expect if you’re about to stop taking the drug. 

  • Days 1-3: At this point, a person will start experiencing withdrawal. The minor symptoms like irritability, nausea, vomiting, and anxiety will be prevalent at this stage. Your brain is slowly adapting to the electric chemistry without Mysoline present, and you’ll likely endure frequent and sudden mood changes. The individual will also deal with dizziness, weakness, distorted vision, and hand tremors. Again, this will vary from one person to another. However, in some cases, around 16 hours after the last dose and anywhere up to five days, a person might encounter delirium or convulsions. Seizures are most likely to happen in those who took significant amounts of the drug, requiring extensive medical monitoring. 
  • Days 4-6: At this point, the acute withdrawal will decrease in severity. However, symptoms like mood swings and insomnia will persist for quite some time. Anxiety will also be severe, especially in those who used barbiturates like Mysoline to treat severe anxiety disorders. However, this is normal as your brain adapts to its new conditions. Only you can tell if something doesn’t feel right, and you must reach out to a medical professional immediately. 
  • Week one and beyond: Once you reach this point, the worst of your acute withdrawal symptoms will subside. However, others might persist for several weeks, months, or in some severe cases, up to a year. Post-acute withdrawal syndrome (PAWS) could occur, which is a condition characterized by mental and emotional withdrawal symptoms that continue beyond the acute stage. In most cases, without professional help, it’ll drive a person to relapse. Even once you’re in the clear for severe symptoms like seizures, you’re still prone to others, making it vital to seek help.

Why Should I Detox?


As was mentioned throughout the article, Mysoline withdrawal can be fatal, and hopefully, we’ve clearly described the imminent dangers without seeking help. Not only is cold turkey an uncomfortable and painful way of stopping, but it can also be dangerous or deadly. Barbiturates are among the most deadly depressants, which is why they’ve been phased out by the medical community. 

The intensity of psychological and physical withdrawal symptoms a person will battle when going through Mysoline withdrawal is much harder without help. For all of the reasons mentioned above, medically assisted detox can be the difference between success and failure, or even life and death. 

Once you check in to medical detox, a group of addiction specialists will thoroughly assess your condition to determine what you’ll need. The process, as a whole, will last anywhere from three to seven days, and you won’t be released until they’re sure you’re in the clear. You’ll also be given medication, as well as support, which improves your chances of long-term recovery.

What Is the Next Treatment Step?

For a person to achieve maximum success, they must remain in treatment for at least 90 days. Those battling addiction must go through the continuum of care to ensure their success long term. While medical detox is an important piece of the puzzle, it’s not enough to guarantee sobriety as it won’t teach coping mechanisms used to battle triggers. For this reason, accepting the next stage of care is vital. 

A person with an extensive history of relapse or a poor living environment will be recommended to seek inpatient residential treatment. It’s similar to the intensity of detox and will include around-the-clock monitoring, and the individual will be assigned to a therapist to visit regularly. 

Those who used Mysoline as prescribed have no history of relapse, and a safe living environment might be able to opt for outpatient care. You’ll be able to go through the same therapy programs as someone living in residential care, but you’ll have the ability to go home once completed. This is ideal for someone who can’t forego important responsibilities like work, school, or leaving their child.

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