Mescaline, which is known chemically as 3,4,5-trimethoxyphenethylamine, is a potent psychedelic that is known for hallucinogenic effects on the brain. The effects are similar to psilocybin and LSD. It is a naturally occurring substance found throughout different cactus species, such as San Pedro, peyote, Peruvian Torch, and many others.

Mescaline is an extremely popular choice for psychedelic lovers, and it is a powerful hallucinogenic drug with deep roots in Mexican culture. It was regularly used as a medium during spiritual and religious ceremonies, but today, there is no approved medical use for the substance. The use of mescaline is considered illicit, but some suggest it is a beneficial holistic treatment for drug addiction and alcoholism.

The drug itself is not believed to be addictive; however, it does present the propensity for abuse. While it may not cause a chemical dependency, it can be psychologically addictive in some who use the drug. Users have described becoming dependent on the drug for emotional and social reasons. Mescaline can be addictive and dangerous in its own way, which can cause withdrawal symptoms in the person abusing it.

What Are The Mescaline Withdrawal Symptoms?

Mescaline is classified by the Drug Enforcement Administration (DEA) as a Schedule I drug. It possesses a high potential for abuse and can produce a host of side effects in its users. The most common effects of abuse are psychological dependence and tolerance from continued use.

Since the substance does not produce a physical dependence, the most common mescaline withdrawal symptoms are emotional and mental as opposed to physical. The most common symptoms include:

  • Anxiety
  • Depression
  • Agitation
  • Insomnia

What Are The Effects Of Mescaline?

Since mescaline itself is not considered addictive, it’s crucial to understand the effects it has on your mind and body. As we described above, it is a potent hallucinogen that can cause several types of nasty effects on the body throughout its 12-hour duration as it remains active in your body. Many people report pleasant effects, but others report adverse feelings from use.

Effects Of Mescaline On The Body

The effects of the drug are going to vary in severity from one person to another. Depending on how much you’ve consumed, or if you have a tolerance, the symptoms will vary in strength. Some may experience mild symptoms, while another person may deal with severe effects. Many of these symptoms are less than desirable, which will potentially cause adverse health consequences for the user.

Physical sensations

The drug produces euphoric effects in the body and mind of its users. It has been described as a feeling of warmth throughout the body. The effects are similar to those of LSD.


The drug will force its users to engage in several different physical activities. Users report feelings of energy, and they may feel compelled to participate in constant and frequent physical motion.

Other common effects include:

  • Appetite suppression
  • Stamina increase
  • Nausea
  • Frequent urination
  • Increased libido
  • Raised heart rate
  • Pupil dilation
  • Seizure

Although seizures are a rare side effect of mescaline consumption, it is still possible. The impact on the mind will vary significantly on an individual basis. Some factors that will determine how someone responds to mescaline include:

  • Dosing (if someone takes too little or too much of the substance)
  • Body chemistry
  • Using the drug in a negative mindset
  • Feeling uncomfortable in your environment prior to using the drug

Regardless of the situation, mescaline will induce profound side effects in your brain. The experience is often reported as euphoric and incite deep feelings of empathy in the body. Many people suggest a new view of the world as a whole following their experience. Other effects that users will experience may include:

  • Euphoria
  • Sociability
  • Love
  • Delusions
  • Time distortion
  • Memory impairment
  • Rapid thoughts

Can Mescaline Cause Psychosis?

One of the primary questions psychedelic users incur is whether the effects will cause long-term damage to the brain.

Many stories describe a person’s inability to return to normal after using too much of a psychedelic. The brain chemistry is altered forever, and they find themselves struggling with cognitive and emotional issues for the remainder of their lives.

Mescaline, like other psychedelics, was the subject of a study that delves into the possibility of experience adverse side effects. The initial research compiled evidence from people who have used hallucinogens.

It showed that people in this group were no more likely to develop mental health issues. Instead, it shows that because psychiatric disorders are common, the correlation between mescaline use and psychosis is a mistake. However, it should not downplay the dangers of the drug.

Many people will experience a dependence on the drug for emotional and mental reasons. Their desire to have spiritual experiences can lead to repetitive use of the drug, which will cause tolerance. Some individuals may experience cravings for the substance.

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